CCR7 представлен на различных раковых клетках, таких как немелкоклеточный рак лёгкого, рак желудка и рак пищевода.[2][3][4] Экспрессия CCR7 на раковых клетках связана с их метастазировением в лимфатические узлы.[5]
Примечания
↑F. Balkwill, Cancer and the Chemokine Network, Nature reviews, 2004
↑Mashino, K. et al. Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. Cancer Res. 62, 2937–2941 (2002)
↑Takanami, I. Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis. Int. J. Cancer 105, 186–189 (2003)
↑Ding, Y. et al. Association of CC chemokine receptor 7 with lymph node metastasis of esophageal squamous cell carcinoma. Clin. Cancer Res. 9, 3406–3412 (2003)
10.1016/j.ccr.2007.04.020. PMID 17560334.
Библиография
Müller G, Lipp M (2003). «Shaping up adaptive immunity: the impact of CCR7 and CXCR5 on lymphocyte trafficking.». Microcirculation (New York, N.Y. : 1994)10 (3–4): 325–34. 10.1038/sj.mn.7800197. PMID 12851649.
Burgstahler R, Kempkes B, Steube K, Lipp M (1995). «Expression of the chemokine receptor BLR2/EBI1 is specifically transactivated by Epstein-Barr virus nuclear antigen 2». Biochem. Biophys. Res. Commun.215 (2): 737–43. 10.1006/bbrc.1995.2525. PMID 7488016.
Schweickart VL, Raport CJ, Godiska R, et al. (1995). «Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2». Genomics23 (3): 643–50. 10.1006/geno.1994.1553. PMID 7851893.
Ссылки
База данных IUPHAR Database of Receptors and Ion Channels. Международный союз фундаментальной и клинической фармакологии.